5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S001000

Reexamination Certificate

active

07022689

ABSTRACT:
The present invention relates to a 5-amidino-N-(2-aminophenethyl)-2-hydroxybenzenesulfonamide derivative represented by the general formula:wherein R1is a hydrogen atom or a lower alkyl group;R2represents a hydrogen atom, an optionally substituted lower alkyl group, etc.;R3is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, etc.;Q is a hydrogen atom or an optionally substituted lower alkyl group; andZ is a hydrogen atom or a hydroxy group, etc.,or a pharmaceutically acceptable salt thereof, which exerts a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

REFERENCES:
patent: WO 97/30971 (1997-08-01), None
patent: WO 00/59876 (2000-10-01), None
patent: WO 02/28827 (2002-04-01), None

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