5-amidino-2-hydroxybenzenesulfonamide derivatives,...

Details 5-amidino-2-hydroxybenzenesulfonamide derivatives,... 5-amidino-2-hydroxybenzenesulfonamide derivatives,...

2007-05-15

2007-05-15

O'Sullivan, Peter (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C514S603000, C544S159000, C548S144000, C548S204000, C562S469000, C564S086000

Reexamination Certificate

active

11359430

ABSTRACT:
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula:wherein R1is a hydrogen atom or an optionally substituted lower alkyl group;R2is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group;T is an oxygen atom, a sulfur atom, a sulfonyl group etc.;Q is a hydrogen atom or an optionally substituted lower alkyl group; andZ is a hydrogen atom, a hydroxy group etc.,or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

REFERENCES:
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patent: 2005/0107354 (2005-05-01), Koizumi et al.
patent: WO 0050390 (2000-08-01), None
patent: WO 0059876 (2000-10-01), None
patent: WO 02/28827 (2002-04-01), None
Leo Alig, et al.; Low Molecular Weight, Non-Peptide Fibrinogen Receptor Antagonists; ;J. Med. Chem., vol. 35, No. 23, pp. 4393-4407 (1992).

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