5-.alpha.-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles

Details 5-.alpha.-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles 5-.alpha.-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles

1985-02-13

1986-06-17

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21357

Patent

active

045957622

ABSTRACT:
3-Q-4-R.sub.2 -5-(2-Q'-5-R.sub.3 -4-thiazolyl)-6-R.sub.1 -2(1H)-pyridinones (I), where R.sub.1 is alkyl having from one to four carbon atoms, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen or alkyl having from one to three carbon atoms, Q is amino, carbamyl, carboxy, cyano or hydrogen, and Q' is alkyl having from one to four carbon atoms, amino or R.sub.4 NH where R.sub.4 is alkyl having from one to four carbon atoms, or acid-addition salts thereof where at least one of Q and Q' is amino or Q' is R.sub.4 NH, are useful as cardiotonics (I where Q is amino, cyano or hydrogen) and/or as intermediates (I where Q is cyano, carbamyl or carboxy). Also shown as intermediates are 1,2-dihydro-4-R.sub.2 -5-[R.sub.3 CH(Br)CO]-6-R.sub.1 -2-oxo-3-pyridinecarbonitriles (II), and, also, processes for preparing I and II.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4312875 (1982-01-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.
patent: 4412077 (1983-10-01), Lesher et al.
patent: 4415580 (1983-11-01), Lesher et al.

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