5'-alkylphosphonylnucleosides as antivirals

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 265, 536 267, A61K 3170

Patent

active

053746260

ABSTRACT:
The present invention relates to the use as antivirals of compounds of formula: ##STR1## wherein B is a purinic or pyrimidinic heterocycle; X is oxygen or sulphur; R.sup.1 is a hydroxyl group or a hydrogen atom; R.sup.2 is a linear, branched or cyclic, alkyl group of up to twenty carbon atoms; R.sup.3 is as specified for R.sup.2 above or a hydrogen atom, a cation or a polyhydroxy group.

REFERENCES:
patent: 3560478 (1971-02-01), Myers
patent: 4469863 (1984-09-01), Tso et al.
patent: 4500707 (1985-02-01), Caruthers et al.
Agris et al., "Inhibition of Vesicular Stomatitis Virus Protein Synthesis and Infection by Sequence-Specific Oligodeoxyribonucleoside Methylphosphonates," Biochemistry, 25, 6268-6275 (1986).
Marugg et al., "Synthesis of Nucleic Acid Methylphosphonates Via the 1-Hydroxybenzotriazole Phosphotriester Approach," Nucleic Acids Research, 14(5), 2171-2185 (1986).
Puech et al., "Synthesis and Biological Evaluation of Isomeric Dinucleoside Monophosphates and Monomethylphosphonates of 9-.beta.-D-Arabinofuranosyladenine and Related Analogues," J. Med. Chem., 31, 1897-1907 (1988).
Kosolapoff et al., "Organic Phosphorus Compounds," vol. 4, Wiley-Interscience, New York, 1972, pp. 269, 269 and 288.
Kochetkov et al., Organic Chemistry of Nucleic Acids, Part A, Plenum Press, New York, 1971, pp. 65-66.
Jager et al., "Synthesis of Methylphosphonate and Methylphosphotriester Analogues of 2',5'-Adenylate Trimers," Nucleic Acids Research Symposium Series, No. 9, IRL Press, Ltd. London, 1981, pp. 149-152.
Santi et al., "Tyrosyl Transfer Ribonucleic Acid Synthetase from E Coli B. Analysis of Tyrosine and Adenosine 5-Triphosphate Binding Sites," J. Med. Chem., 16(3), 277-280 (1973).
Griengl et al., "Phosphonoformate and Phosphonoacetate Derivatives of 5-substituted-2'-deoxyuridines: Synthesis and Antiviral Activity," J. Med. Chem., 31(9), 1831-1839 (1988).
Lambert et al., "Synthesis and Antiviral Activity of Phosphonoacetic and Phosphonoformic Acid Esters of 5-Bromo-2'-deoxyuridines and Related Pyrimidine Nucleosides and Acylclonucleosides," J. Med. Chem. 32(2), 367-374 (1989).
Journal of Medicinal Chemistry, vol. 16, No. 3, Mar. 1973, D. V. Santi et al.: "Tyrosyl transfer ribonucleic acid synthetase from escherichia coli B".
Journal of Medicinal Chemistry, vol. 31, No. 9, Sep. 1988, H. Griengl et al. : "Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and activiral activity", pp. 1831-1839, see the whole document
Journal of Medicinal Chemistry, vol. 32, No. 2, Feb. 1989, R. W. Lambert, et al.: "Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides": , pp. 367-374, see the whole document.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

5'-alkylphosphonylnucleosides as antivirals does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5'-alkylphosphonylnucleosides as antivirals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5'-alkylphosphonylnucleosides as antivirals will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2386324

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.