5-alkyl tetramic acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D20736

Patent

active

049837435

ABSTRACT:
A process for the production of 5-alkyl tetramic acids from 4-alkoxy-3-pyrrolin-2-ones and aldehydes or ketones. By basic catalysis, 5-alkylidene-4-alkoxy-3-pyrrolin-2-ones are first formed, which are converted into the target compounds by cleavage of the alkoxy group and catalytic hydrogenation.

REFERENCES:
patent: 2328232 (1943-08-01), Schnider
patent: 4788294 (1988-11-01), Duc et al.
patent: 4824966 (1989-04-01), Meul et al.
patent: 4843166 (1989-06-01), Meul
patent: 4855451 (1989-08-01), Meul
Altenbach, H. J., Nachr, Chem. Tech. Lab., 36 (1988), pp. 756 to 758.
T. P. C. Mullholland et al., "Synthesis of Pyrrolidine-2,4-Diones (Tetramic Acids) and Some Derivatives", Jnl. of Chem. Soc., Perkin Trans. I (1972), Organic and Bio-Organic Chemistry, pp. 2121-2128.
Patrick Jouin et al., "Stereospecific Synthesis of N-Protected Statine and its Analogues via Chiral Tetramic Acid", Jnl. Chem. Soc., Perkin Trans. I (1987) Organic and Bio-Organic Chemistry, pp. 1177-1182.
Jones et al., "A Synthesis of 3-Acyl-5-Alkyl Tetramic Acids", Tetrahedron Lett., (1978), pp. 3173-3176.
S. A. Harris et al., J. Med. Chem., 8, (1965), pp. 478-482.
G. Stork et al., "Carboxy-.beta.-Lactams by Photochemical Ring Contraction", J. Am. Chem. Soc., 96, (1974) pp. 5787-5791.
C. O. Gitterman, "Antitumor, Cytotoxic, and Anibacterial Activities of Tetrazonic Acid and Congeneric Tetramic Acids", J. Med. Chem., 8, (1965), pp. 483-486.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

5-alkyl tetramic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-alkyl tetramic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-alkyl tetramic acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-935931

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.