5-alkyl indole compounds

Details 5-alkyl indole compounds 5-alkyl indole compounds

1996-12-16

1999-12-07

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548468, A61K 3140, C07D40306

Patent

active

059984627

ABSTRACT:
Described herein are compounds selective for the 5-HT.sub.1D -like receptor, which have the general formula: ##STR1## wherein: R.sup.1 is linear or branched loweralkyl;

REFERENCES:
patent: 4870085 (1989-09-01), Glaser et al.
patent: 5348968 (1994-09-01), Lavielle et al.
patent: 5496957 (1996-03-01), Glennon
patent: 5504101 (1996-04-01), Glennon
Glen, et al. Journal of Medicinal Chemistry, 1995, 38:3566-3580. "Computer-Aided Design and Synthesis of 5-Substituted Tryptamines and Their Pharmacology at the 5-HT1D Receptor: Discovery of Compounds with Potential Anti-Migraine Properties".
Chemical Abstracts, vol. 97, No. 17, Oct., 1982, abs. No. 144720k, Banglun et al. "Synthesis of N,N-disubstituted beta-hydroxy-tryptamines."
Macor, John, A direct synthesis of 3-(pyrrolidin-3-yl)indoles for Use as Conformationally Restricted Analogs of Tryptamines (Apr., 1997), pp. 443-449, Synthesis.

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