5-alkyl-6-[[amino]methyl]pyrido[2,3-D]pyrimidine derivatives and

Details 5-alkyl-6-[[amino]methyl]pyrido[2,3-D]pyrimidine derivatives and 5-alkyl-6-[[amino]methyl]pyrido[2,3-D]pyrimidine derivatives and

1992-09-23

1994-09-13

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47104

Patent

active

053469003

ABSTRACT:
This invention discloses a compound and pharmaceutically acceptable salts having the formula: ##STR1## wherein X and Y are the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein R.sub.1 is selected from the group consisting of hydrogen, a first lower alkyl group, a nitroso group and an aldehyde; and wherein R.sub.2 is selected from the group consisting of a second lower alkyl group which is the same as or different than the first lower alkyl group, an aryl group, an alkylaryl group, a substituted aryl group and a substituted alkylaryl group, and each substituent of the substituted aryl group or the substituted alkylaryl group is the same or different and is selected from the group consisting of a third lower alkyl group which is the same as or different than the first lower alkyl group or the second lower alkyl group, an alkoxy group, a substituted alkoxyaryloxy group and a halogen; and wherein R.sub.3 is a fourth lower alkyl group which is the same as or different than said first lower alkyl group, said second lower alkyl group or said third lower alkyl group. Methods of preparing and using these compounds are disclosed.

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