5-alkenyl and 5-alkynyl indole compounds

Details 5-alkenyl and 5-alkynyl indole compounds 5-alkenyl and 5-alkynyl indole compounds

1996-12-16

1999-01-05

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514397, 514415, 548468, 548469, 548491, 548504, C07D40302, C07D20902, C07D20904, C07D20916, A61K 31415, A61K 31405

Patent

active

058565108

ABSTRACT:
Described herein are compounds selective for 5-HT.sub.1D -like receptors, which have the general formula: ##STR1## wherein: R.sup.1 is selected from H, aryl and aryl substituted with 1, 2 or 3 substituents independently selected from loweralkyl, loweralkoxy, loweralkylcarbonyl, loweralkyl-S--, loweralkyl-S(O)--, loweralkyl-SO.sub.2 -, S.dbd.C.dbd.N--, O.dbd.C.dbd.N--, halo, loweralkoxycarbonyl, nitro, amino, loweralkyl-NH--, (loweralkyl).sub.2 --N--, loweralkyl-SO.sub.2 -loweralkyl-;

REFERENCES:
patent: 4870085 (1989-09-01), Glaser et al.
patent: 5348968 (1994-09-01), Lavielle et al.
patent: 5496957 (1996-03-01), Glennon
patent: 5504101 (1996-04-01), Glennon
Glen, et al. Journal of Medicinal Chemistry, 1995, 38:3566-3580.
"Computer-Aided Design and Synthesis of 5-Substituted Tryptamines and Their Pharmacology at the 5-HT1D Receptor: Discovery of Compounds with Potential Anti-Migraine Properties".

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