5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceut

Details 5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceut 5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceut

1994-04-13

1996-07-09

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514294, 514314, 546 95, 546169, 548128, C07D28512, A61K 3141

Patent

active

055345301

ABSTRACT:
The invention relates to thiadiazole derivatives corresponding to the general formula ##STR1## in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom with CO--(C.sub.1 -C.sub.4)alkyl; with (CH.sub.2).sub.n COR in which n represents 1 or 2 and R represents OR.sub.1 or NR.sub.1 R.sub.2 with R.sub.1 and R.sub.2, which may be identical or different, representing H or (C.sub.1 -C.sub.4)alkyl; with (C.sub.1 -C.sub.4) hydroxyalkyl; with (C.sub.2 -C.sub.6) alkoxyalkyl; tetrahydropyranyl; or with a --(CH.sub.2).sub.3 -- chain, the last carbon of which is attached to the phenyl ring of the indole to form a 6-membered ring;

REFERENCES:
patent: 5189049 (1993-02-01), Frehel
Mylari, J. Med. Chem. 33 2019 (1990).

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