5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure

Details 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure

1990-11-09

1992-06-02

Rothman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546242, 546261, 546283, 546284, 546288, 546298, C07D21364, C07D21380, A61K 3144

Patent

active

051186969

ABSTRACT:
Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

REFERENCES:
patent: 4568751 (1986-02-01), Jones et al.
patent: 4731371 (1988-03-01), Jones et al.
patent: 4853395 (1989-08-01), Jones et al.
patent: 4992452 (1991-02-01), Jones et al.

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