5-acyl-1,4-dihydropyridines

Details 5-acyl-1,4-dihydropyridines 5-acyl-1,4-dihydropyridines

1997-02-11

1999-08-24

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, C07D21186, A61K 31455

Patent

active

059425261

ABSTRACT:
The present invention relates to the new use of 1-alkyl-3,5-diacyl-1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.

REFERENCES:
patent: 3966948 (1976-06-01), Bossert et al.
patent: 5446057 (1995-08-01), Augelli-Szafran et al.
V.K. Lusis, et al., Chem. Het. Compounds (English Translation), vol. 19, pp. 415-419, (1983).
P.W.L. Tas, et al., Neuroscience Letters, vol. 94 pp. 279-284, (1988).

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