5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S143000

Reexamination Certificate

active

08034829

ABSTRACT:
The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

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patent: WO 2005/075431 (2005-08-01), None
patent: WO 2005/075432 (2005-08-01), None
E. M. Kaiser et al., “Facile Synthesis of 1-Amino-3-arylisoquinolines”, Synthesis, No. 11, 1974, pp. 805-806.
P. J. Pijper et al., “Synthesis and antimycoplasmal activity of 2, 2′-bipyridyl analogs,, Part I. 1-Amino-3-(2-pyridyl) isoquinolines”, European Journal of Medicinal Chemistry, vol. 19, No. 5, 1984, pp. 389-392.
H. Van Der Goot et al., “The growth-inhibitory action of some 1-aminoisoquinolines and related compounds on mycoplasma gallisepticum”, European Journal of Medicinal Chemistry, vol. 10, No. 6, 1975, pp. 603-606.
H. Van Der Goot et al., “A new synthesis of 1 aminoisoquinolines” Chimica Therapeutica, vol. 7, No. 3, 1972, pp. 185-188.
W.-J. Cho et al., “Synthesis of New 3-Arylisoquinolinamines: Effect on Topoisomerase I Inhibition and Cytotoxicity”, Bioorganic & Medicinal Chemistry Letters, vol. 13, No. 24, 2003, pp. 4451-4454.
Molecular Modeling of 3-Arylisoquinoline Antitumor Agents Active Against A-549. A Comparative Molecular Field Analysis Study, Bioorganic & Medicinal Chemistry 10, (2002), pp. 2953-2961.

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