5,6-Methano-5,6-dihydroretinoids

Details 5,6-Methano-5,6-dihydroretinoids 5,6-Methano-5,6-dihydroretinoids

1982-09-22

1984-03-27

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560119, 562501, 562405, 568374, 568445, 568819, 424308, 424298, 424315, 564123, C07C 6976, C07C 6974

Patent

active

044396147

ABSTRACT:
5,6-Methano-5,6-dihydroretinoids such as ethyl (E)-5,6-methano-5,6-dihydroretinoate and (E)-1-(4-carbethoxyphenyl)-2-methyl-4-(2,2,6-trimethylbicyclo[4.1.0]hept-1 -yl)-1,3-butadiene are disclosed. These componds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

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