5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin an

Details 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin an 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin an

1985-06-27

1986-09-02

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549459, A61K 31335, A61K 31557, C07D30700

Patent

active

046096710

ABSTRACT:
5-6-Epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## wherein A is CH.dbd.CH or (CH.sub.2).sub.2, m is 1 to 8, n is 0 to 5, R is H, lower alkyl, alkali metal or hydroxylamine salt, and R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, lower alkenyl, lower alkoxy, aralkoxy or ##STR2## including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4416896 (1983-11-01), Nakane
patent: 4456617 (1984-06-01), Nakane

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