5,6-dihydropyrone derivatives as protease inhibitors and antivir

Details 5,6-dihydropyrone derivatives as protease inhibitors and antivir 5,6-dihydropyrone derivatives as protease inhibitors and antivir

1994-10-12

1998-11-24

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514269, 514336, 514397, 549292, 549417, 5483111, 546268, 544298, 544315, A61K 3135, A61K 31415, A61K 3144, A61K 31505

Patent

active

058407510

ABSTRACT:
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.

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