5,6-dihydropyrone derivatives as protease inhibitors and antivir

Details 5,6-dihydropyrone derivatives as protease inhibitors and antivir 5,6-dihydropyrone derivatives as protease inhibitors and antivir

1994-10-12

1998-08-04

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142278, 5142322, 514255, 514314, 514336, 514374, 514378, 514397, 514414, 514422, 514432, 514444, 514451, 514459, 549 28, 549 60, 549292, 549293, 549294, 549426, 549427, 546135, 5462821, 544 60, 544149, 544374, 548247, 548235, 5483111, 548465, 548509, 548517, A61K 3135, A61K 3138, A61K 3140, A61K 3142, A61K 31495, A61K 3154

Patent

active

057894400

ABSTRACT:
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.

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