5,6-Dihydro analogues of prostaglandin I.sub.2

Details 5,6-Dihydro analogues of prostaglandin I.sub.2 5,6-Dihydro analogues of prostaglandin I.sub.2

1978-10-12

1980-06-03

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034622, 424283, 424285, 542422, C07D31194, C07D30793

Patent

active

042061270

ABSTRACT:
Derivatives of prostaglandin I.sub.2 characterized by the generic structural formulae, ##STR1## are useful for inhibiting platelet aggregation or gastric acidity in individuals for whom such therapy is indicated. In the preceding structural formulae: B is CH.sub.2 OH or COOT, where T is hydrogen, an alkyl group having from 1-3 carbon atoms or a pharmacologically acceptable cation; X and Y are hydrogen or a hydroxyl group; A is methylene or ethylene; and R is a pentyl, cyclohexyl, bicyclo[3.2.0]-hept-3-yl or 1, 1-dimethylpentyl group.

REFERENCES:
patent: 4123441 (1978-10-01), Johnson

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