5,6-Didehydro-.omega.-phenoxy-PGE.sub.2 analogs

Details 5,6-Didehydro-.omega.-phenoxy-PGE.sub.2 analogs 5,6-Didehydro-.omega.-phenoxy-PGE.sub.2 analogs

1976-11-04

1978-09-05

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560 53, 562463, 260408, 260413, 2604105, C07C 6522, C07C17700

Patent

active

041119690

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3773795 (1973-11-01), Bagli et al.
patent: 3816393 (1974-06-01), Hayashi et al.
Pattersn, J. W., Jr., J. Org. Chem., vol. 39, No. 17, 1974, pp. 2506-2509.

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