Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1986-11-03
1988-03-15
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
560 53, 564226, 564247, 564225, 546204, 548353, 548569, 544294, C07C 6994
Patent
active
047314702
ABSTRACT:
The invention relates to novel [(5,6-dichloro-3-oxo-2,9a-alkano--2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy] alkanoic acids and alkanimidamides, their derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections including that due to AIDS virus, various brain concussions and elevated intracranial pressure.
REFERENCES:
patent: 4316043 (1982-02-01), Cragoe et al.
patent: 4317922 (1982-03-01), Cragoe et al.
patent: 4337354 (1982-06-01), Cragoe et al.
patent: 4356313 (1982-10-01), Cragoe et al.
patent: 4356314 (1982-10-01), Cragoe et al.
"Agents for the Treatment of Brain Injury", J. Med. Chem., (1982), 25, 567-579--Cragoe, et al.
"Agents for the Treatment of Brain Edema", J. Med. Chem., (1986) 29, 825-841--Cragoe, et al.
Cragoe, Jr. Edward J.
Pietruszkiewicz Adolph M.
Woltersdorf, Jr. Otto W.
Caruso Charles M.
Killos Paul J.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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