5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory

Details 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory

1976-03-10

1977-05-03

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 3153

Patent

active

040215539

ABSTRACT:
A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are C.sub.1 -C.sub.3 alkoxy or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically-acceptable acid addition salts of basic members thereof.

REFERENCES:
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H. Neunhoeffer et al., Justus Liebigs Ann. Chem., 760, 88 (1972).
H. Neunhoeffer et al., Chem. Ber. 101, 3952 (1968).

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