5,6-Diaryl-1,2,4-triazines

Details 5,6-Diaryl-1,2,4-triazines 5,6-Diaryl-1,2,4-triazines

1978-10-18

1980-02-26

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D25306

Patent

active

041907256

ABSTRACT:
5,6-Diaryl-1,2,4-triazines, topically-active anti-inflammatory agents, having the formula, ##STR1## wherein R is hydrogen or -(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are C.sub.1 -C.sub.3 alkoxy or di(C.sub.1 -C.sub.3 alkyl)amino; with the proviso that when R.sub.2 and R.sub.3 both are methoxy, R cannot be H or methylthio; and the pharmaceutically-acceptable acid addition salts of basic members thereof.

REFERENCES:
patent: 3948894 (1976-04-01), Lacefield
patent: 3979516 (1976-09-01), Lacefield
patent: 3989831 (1976-11-01), Lacefield
patent: 4008232 (1977-02-01), Lacefield
patent: 4013654 (1977-03-01), Lacefield
patent: 4018923 (1977-04-01), Lacefield
patent: 4021553 (1977-05-01), Lacefield

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