5,6-DIARYL-1,2,4-TRIAZINES

Details 5,6-DIARYL-1,2,4-TRIAZINES 5,6-DIARYL-1,2,4-TRIAZINES

1976-03-10

1977-03-22

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424249, C07D25306

Patent

active

040136540

ABSTRACT:
5,6-Diaryl-1,2,4-triazines, topically-active anti-inflammatory agents, having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino, with the proviso that at least one of R.sub.2 and R.sub.3 is halo or C.sub.1 -C.sub.3 alkyl; and the pharmaceutically-acceptable acid addition salts of basic members thereof.

REFERENCES:
neunhoeffer et al., Ann. der Chemie, pp. 88-101, vol. 760 (1972).
Neunhoeffer et al., Chem. Ber., pp. 3952-3956, vol. 101 (1968).
Polonovski et al., Chemical Abstracts, vol. 46, 514(b) 1952.
Polonovski et al., Chemical Abstracts, vol. 47, 11209e (1953).
Laakso et al., Chem. Abstr., vol. 51, 13875i (1957).
Metze et al., Chem. Abstr., vol. 51, 15532d (1957).
Neunhoeffer et al., Chem. Abstr., vol. 75, 129773g (1971).

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