[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)o

Details [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)o [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)o

1980-12-19

1982-02-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

42424854, 42424855, 424250, 424260, 424262, 424263, 424267, 424274, 424275, 424285, 424308, 424317, 424324, 424309, 26032643, 2603473, 2603474, 260463, 544155, 544294, 544380, 546194, 546285, 548201, 548346, 549 29, 562461, C07C 6994

Patent

active

043160433

ABSTRACT:
The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.

REFERENCES:
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patent: 3933905 (1976-01-01), Brunet
patent: 3974212 (1976-08-01), Cragoe et al.
patent: 4070460 (1978-01-01), Galner
patent: 4096267 (1978-06-01), Cragoe, Jr. et al.
de Solms, S. J. et al., Journal of Med. Chem., 21, 437 (1978).
Gaab, M.; Journal of Neurol 220, 185-197 (1979).
Kumar, A. M. et al., Journal Physiol. (1977), 272 pp. 563-572.
Hartman, A. et al., Arch. Psydnal Nervenkr 224 351-360, (1977).
Tomheim, P. A., Anatomical Record, 19, Oct. 1978.

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