[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahy dro-3H-fluoren-7-yl)

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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26032643, 2603473, 2603474, 260463, 544155, 544294, 544380, 546194, 546285, 548201, 548346, 549 29, 560 53, 42424854, 42424855, 424250, 424260, 424262, 424263, 424267, 424274, 424275, 424285, 424308, 424309, 424317, 424324, C07C 6994

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043179223

ABSTRACT:
The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.

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deSolms, S. J., et al., Journal of Med. Chem., 21, 437 (1978).
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Kumar, A. M. et al., Journal Physiol. (1977), 272, pp. 563-572.
Hartman, A., et al., Arch. Psychial. Nervenkr. 224, 351-360 (1977).
Tomheim, P. A., Anatomical Record, 19, Oct. 1978.

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