[(5,6,9a-substituted-3-oxo-1,2,9,9a-tet rahydro-3H-fluoren-7-yl)

Details [(5,6,9a-substituted-3-oxo-1,2,9,9a-tet rahydro-3H-fluoren-7-yl) [(5,6,9a-substituted-3-oxo-1,2,9,9a-tet rahydro-3H-fluoren-7-yl)

1981-02-19

1982-10-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260463, 544155, 544294, 544380, 546194, 546285, 548201, 548346, 548573, 549 29, 549501, 562461, 42424854, 42424855, 424260, 424250, 424262, 424263, 424267, 424274, 424275, 424285, 424308, 424317, 424309, 424324, C07C 6994

Patent

active

043563139

ABSTRACT:
The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoi c and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.

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patent: 4096267 (1978-06-01), Cragoe, Jr. et al.
de Solms S. J. et al., Journal of Med. Chem., 21, 437, (1978).
Gaab, M., Journal of Neurol. 220, 185-197, (1979).
Kumar, A. M. et al., Journal Physiol., (1977), 272, pp. 563-572.
Hartman, A. et al., Arch. Psychiat. Nervenkr., 224, 351-360, (1977).
Tomheim, Pin, Anatomical Record, 19, Oct. 1978.

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