5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and an

Details 5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and an 5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and an

1984-01-03

1986-01-14

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514444, 514460, 514468, 546269, 549 60, 549414, 549415, 549458, A61K 3134, C07D30793

Patent

active

045646201

ABSTRACT:
Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17-.alpha.-methyl-20-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI.sub.2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI.sub.2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentanor-1 5-phenyl PGI.sub.2. They are useful in treatment of ulcers, thrombii and hypertension for example.

REFERENCES:
patent: 4301164 (1981-11-01), Ohno et al.

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