Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-04-23
1994-07-05
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514510, 514662, 549451, 560107, 560251, 560252, 564427, A61K 3113, C07C22520
Patent
active
053267869
ABSTRACT:
Compounds represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or a protective group for a hydroxyl group, or R.sub.1 and R.sub.2 combine to represent a protective group for hydroxyl groups, and
REFERENCES:
van Temelen et al.,"The Synthesis of Colchicine", Tetrahedron, 1961, vol. 14, pp. 8-34, Pergamon Press.
Leiter et al., "Damage Induced in Sarcoma 37 with Chemical Agents. IV. Derivatives of Colchiceinamide.sup.1 ", Journal of the National cancer-Institute, 13, pp. 731-739 (1952).
Davis, "Microbial Transformations of N-Methylcolchiceinamide", Antimicrobial Agents and Chemotherapy, Mar. 1981, vol. 19, No. 3, pp. 465-469.
Hartwell et al., "N-Substituted Colchicainamides", J. Am. Chem. Soc., vol. 74 pp. 3180-3181 (1952).
Ohgen Research Laboratories Ltd.
Raymond Richard L.
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