5,6,7,8 Tetrahydroquinoline derivatives

Details 5,6,7,8 Tetrahydroquinoline derivatives 5,6,7,8 Tetrahydroquinoline derivatives

1975-04-15

1976-11-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283S, 260283CN, 2602949, 260295F, 260289K, 260289R, 260586R, 2602948C, C07D21520, C07D21548

Patent

active

039910601

ABSTRACT:
The invention provides a compound of formula I ##SPC1##
or an acid addition salt thereof, wherein R.sup.1, R.sup.2 and R.sup.4 are the same or different and represent hydrogen, or a lower alkyl radical, R.sup.5 represents hydrogen or single or multiple substitution by lower alkyl radicals, X is cyano, CONHR.sup.3, CSNHR.sup.3 or CO.sub.2 R.sup.3 wherein R.sup.3 is hydrogen or a lower alkyl radical, m is 1, 2 or 3 and R.sup.6 is hydrogen, a lower alkyl radical or a lower alkanoyl radical or an alkali-metal salt of a compound in which X is CO.sub.2 H.
Compounds of formula I wherein X is CN or CSNHR.sup.3 and R.sup.6 is lower alkyl are anti-ulcer agents. The other compounds of formula I are intermediates.

REFERENCES:
patent: 3632590 (1972-01-01), Leroi
patent: 3692790 (1972-09-01), Archer
patent: 3726878 (1973-04-01), Kanai et al.
patent: 3751418 (1973-08-01), Weyer
patent: 3813398 (1974-05-01), Aumuller

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