5,6,7,8-Tetrahydronaphthalene hypotensive agents

Details 5,6,7,8-Tetrahydronaphthalene hypotensive agents 5,6,7,8-Tetrahydronaphthalene hypotensive agents

1977-11-14

1981-05-12

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

2603437, 26034829, 260349, 26050118, 26050119, 424280, 424316, 424330, 564184, 564413, C07C 8764

Patent

active

042673739

ABSTRACT:
5,6,7,8-Tetrahydronaphthalenes having the structure ##STR1## and the pharmaceutically acceptable salts thereof, are useful as blood pressure lowering agents. In the above formula R.sub.1 can be hydrogen or alkyl; R.sub.2 is alkyl; R.sub.3 and R.sub.4 can each be hydrogen, hydroxyl, alkoxy, or arylalkoxy, but both cannot be hydroxyl. Those compounds wherein at least one of R.sub.3 and R.sub.4 is other than hydrogen are novel, and constitute a part of this invention.

REFERENCES:
patent: 3579582 (1971-05-01), Symon
Chiemprasert et al., "Chemical Abstracts", vol. 63, pp. 8274-8276 (1965).
Bamberger et al., "Ann. Chemie", vol. 288, pp. 74-80, (1896).
Bamberger et al., "Chem. Ber.", vol. 26, pp. 1833-1844 (1893).
Thrift et al., "J. Chem. Soc. Lond.", vol. C, pp. 288-293 (1967).

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