Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1976-05-06
1977-11-08
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
260315, C07D20988, A61K 3140
Patent
active
040576400
ABSTRACT:
Carbazoles of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,
R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, or
R.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, and
R.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,
And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,
And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.
REFERENCES:
Collar et al., "J. Chem. Soc.," (1926), pp. 808-810.
Barclay et al., "J. Chem. Soc.," (1945), pp. 530-533.
Murphy, "J. Amer. Pharm. Assoc.," vol. 40 (1951), pp. 373-376.
Ahrens Hanns
Biere Helmut
Koch Henning
Rufer Clemens
Schroder Eberhard
Jiles Henry R.
Ramsuer R. W.
Schering Aktiengesellschaft
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