5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]-azepine derivatives

Details 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]-azepine derivatives 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]-azepine derivatives

1988-11-21

1990-10-02

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540578, C07D22300, A61K 3155

Patent

active

049607693

ABSTRACT:
The present invention relates to novel compounds of the following formula: ##STR1## wherein R.sup.1 is alkyl, alkenyl, alkynyl, branched or unbranched, with 1-6 carbon atoms either unsubstituted or optionally substituted with fluoro, hydroxy or phenyl, in which the phenyl group may be substituted with halogen,trifluoromethyl, lower alkyl, hydroxy or lower alkoxy;

REFERENCES:
patent: 4608378 (1986-08-01), Falck et al.
patent: 4859666 (1989-08-01), Eison et al.
Birdsdall N. J. M., Hulme E. C., and Burgen A. S. V. (1980), "The Character of Muscarinic Receptors in Different Regions of the Rat Brain", Proc. Roy. Soc. London (Series B) 207,1.
Watson M., Yamamura H. I., and Roeske W. R. (1983), "Aunique Regulatory Profile and Regional Distribution of [.sup.3 H]-Pirenzepine Binding in the Rat Provide Evidence for Distinct M.sub.1 and M.sub.2 Muscarinic Receptor Subtypes", Life Sci. 32, 3001-3011.
Krogsgaard-Larser et al., J. Neurochemistry, vol. 39, No. 5 (1982), pp. 1319-1324.

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