Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-03-14
1998-06-16
Lankford, Jr., Leon B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483114, 435238, A01N 4350
Patent
active
057671400
ABSTRACT:
A series of 5,5-disubstituted Hydantoin derivatives synthesized by alkylating 5,5-bis(thiomethyl)-2,4-imidazolidinedione with halomethyl aromatic or halomethyl heteroaromatic precursors or by using the Buchener-Berg procedure on the required ketone. This series of 5,5-disubstituted Hydantoin derivatives are biologically active in their ability to inhibit HIV-induced death and virus production in mammalian (human) cells.
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Rodgers et al. J. Med. Chem 20(4) 1977 pp. 591-594.
Comber et al. J. Med. Chem 35(19) 1992 pp. 3567-3572.
Buckheit, Jr. Robert W.
Comber Robert N.
Reynolds Robert C.
Lankford , Jr. Leon B.
Southern Research Institute
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