5,5-Disubstituted hydantoins

Details 5,5-Disubstituted hydantoins 5,5-Disubstituted hydantoins

1995-03-14

1998-06-16

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483114, 435238, A01N 4350

Patent

active

057671400

ABSTRACT:
A series of 5,5-disubstituted Hydantoin derivatives synthesized by alkylating 5,5-bis(thiomethyl)-2,4-imidazolidinedione with halomethyl aromatic or halomethyl heteroaromatic precursors or by using the Buchener-Berg procedure on the required ketone. This series of 5,5-disubstituted Hydantoin derivatives are biologically active in their ability to inhibit HIV-induced death and virus production in mammalian (human) cells.

REFERENCES:
patent: 3547948 (1970-12-01), Shen et al.
patent: 3655692 (1972-04-01), Shen et al.
Rodgers et al. J. Med. Chem 20(4) 1977 pp. 591-594.
Comber et al. J. Med. Chem 35(19) 1992 pp. 3567-3572.

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