5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic

Details 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic

1982-08-25

1984-09-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546280, 546288, C07D41704, A61K 3144

Patent

active

044696990

ABSTRACT:
3-Q-4-R.sub.2 -5-(2-Q'-5-R.sub.3 -4-thiazolyl)-6-R.sub.1 -2(1H)-pyridinones (I), where R.sub.1 is alkyl having from one to four carbon atoms, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen or alkyl having from one to three carbon atoms, Q is amino, carbamyl, carboxy, cyano or hydrogen, and Q' is alkyl having from one to four carbon atoms, amino or R.sub.4 NH where R.sub.4 is alkyl having from one to four carbon atoms, or acid-addition salts thereof where at least one of Q and Q' is amino or Q' is R.sub.4 NH, are useful as cardiotonics (I where Q is amino, cyano or hydrogen) and/or as intermediates (I where Q is cyano, carbamyl or carboxy). Also shown as intermediates are 1,2-dihydro-4-R.sub.2 -5-[R.sub.3 CH(Br)CO]-6-R.sub.1 -2-oxo-3-pyridinecarbonitriles (II), and, also, processes for preparing I and II.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4312875 (1982-01-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.
Ariesan et al., Chemical Abstracts, vol. 74, No. 23, Abst. No. 125,358g, Jun. 7, 1971.

Affiliated with

Also associated with

Rating

5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1891933