5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-

Details 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole- 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-

1981-05-04

1982-05-11

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, C07D40106

Patent

active

043294707

ABSTRACT:
2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a 5-(4-phenyl-1-piperidinyl)methyl substituent, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 5-bromomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivative.

REFERENCES:
patent: 2441933 (1948-05-01), Duschinsky
patent: 2514380 (1950-07-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
Morrison and Boyd, "Organic Chemistry", 3rd Edition, (1973), pp. 745-746, (Allyn and Bacon).
Duschinsky and Dolan, "J. Am. Chem. Soc.", vol. 68, pp. 2350-2355, (1946), vol. 70, pp. 657-662, (1948).
Fed. Proc. 39:1105, (1980), Abstract, Dage et al.
Boularand et al., "Chimie Ther.", vol. 8, pp. 638-646, (1973).

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