5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxyl

Details 5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxyl 5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxyl

1984-05-15

1986-03-04

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549468, A61K 3134, C07D30785

Patent

active

045741280

ABSTRACT:
5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxylic acids of the formula I ##STR1## in which R.sup.1 and R.sup.2 are identical or different and represent hydrogen, halogen or methyl, both as racemic mixtures and in the form of their optical isomers, and their physiologically tolerated salts are described, as is their preparation. They are outstanding diuretics and saluretics with an additional uricosuric component.

REFERENCES:
patent: 3055930 (1982-09-01), Graf et al.
patent: 4156732 (1979-05-01), Lang et al.
patent: 4163794 (1979-08-01), Cragoe, Jr. et al.
Hoffman et al., J. Med. Chem., vol. 24, pp. 865-873, (1981).

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