Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1995-06-05
1998-01-27
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435238, 549282, A01N 102, C07D49300
Patent
active
057120854
ABSTRACT:
Psoralen compounds are synthesized which have substitutions on the 4,4',5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. Also disclosed are compositions comprising 4' or 5'-primary amino substituted psoralens in a synthetic media.
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Isaacs Stephen T.
Nerio Aileen
Rapoport Henry
Spielmann Hans Peter
Wollowitz Susan
Carroll Peter G.
Cerus Corporation
Saucier Sandra E.
LandOfFree
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