5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and card

Details 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and card 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and card

1984-01-16

1985-09-03

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, 546288, C07D40104, A61K 3144

Patent

active

045393273

ABSTRACT:
3-Q-4-R.sub.2 -5-(2-Q'-5-R.sub.3 -4-thiazolyl)-6-R.sub.1 -2(1H)-pyridinones (I), where R.sub.1 is alkyl having from one to four carbon atoms, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen or alkyl having from one to three carbon atoms, Q is amino, carbamyl, carboxy, cyano or hydrogen, and Q' is alkyl having from one to four carbon atoms, amino or R.sub.4 NH where R.sub.4 is alkyl having from one to four carbon atoms, or acid-addition salts thereof where at least one of Q and Q' is amino or Q' is R.sub.4 NH, are useful as cardiotonics (I where Q is amino, cyano or hydrogen) and/or as intermediates (I where Q is cyano, carbamyl or carboxy). Also shown as intermediates are 1,2-dihydro-4-R.sub.2 -5-[R.sub.3 CH(Br)CO]-6-R.sub.1 -2-oxo-3-pyridinecarbonitriles (II), and, also, processes for preparing I and II.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4312875 (1982-01-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.

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