5-(2-hydroxy-1-arylethylidene)- and 5-(2-oxo-1-arylethylidene)-2

Details 5-(2-hydroxy-1-arylethylidene)- and 5-(2-oxo-1-arylethylidene)-2 5-(2-hydroxy-1-arylethylidene)- and 5-(2-oxo-1-arylethylidene)-2

1992-06-30

1993-08-17

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548183, C07D27734, A61K 31425

Patent

active

052369412

ABSTRACT:
5-(2-Hydroxy-1-phenyl (or-1-naphthalenyl)ethylidene) and 5-(2-oxo-1-phenyl (or 1-naphthalenyl)ethylidene)-2,4-thiazolidinediones and derivatives thereof are useful in lowering blood glucose levels in a hyperglycemic laboratory animal model and are thus useful in the treatment of diabetes mellitus.

REFERENCES:
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patent: 5061717 (1991-10-01), Clark et al.
patent: 5068342 (1991-11-01), Zask et al.
patent: 5116855 (1992-05-01), Inoue
patent: 5120754 (1992-06-01), Clark et al.
Omar et al., Bull. Chem, Soc. Jpn., 64, 750-52 (1991).
Salama et al., Alex. J. Pharm. Sci. 4(1), 44-46 (1990).
Zask et al., J. Med. Chem. 33, 1418-23 (1990).
Yoshioka, et al., J. Med. Chem. 32, 421-28 (1989).
Fujita, et al., Diabetes 32, 804-810 (1983).

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