5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic aci

Details 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic aci 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic aci

1982-10-08

1985-08-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548453, C07D20726, A61K 3140

Patent

active

045336717

ABSTRACT:
New 5-(2,3-dihydro-1H-pyrrolizin-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]thiazol-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]imidazol-5-oyl)-, and 5-(2,3-dihydro-1H-pyrrolo[2,1-b]oxazol-5-oyl)-pyrrole-2-alkanoic acid derivatives have been prepared. They are found to be effective inhibitors of platelet aggregation and are analgesic and anti-inflammatory agents with low ulcerogenic side effects.

REFERENCES:
patent: 3952012 (1976-04-01), Carson
patent: 4048191 (1977-09-01), Carson
patent: 4087539 (1978-05-01), Muchowski
patent: 4097579 (1978-06-01), Muchowski
patent: 4119639 (1978-10-01), Carson
patent: 4232038 (1980-11-01), Muchowski
Carson & Wong, J. Med. Chem., 16 (2),172 (1973).

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