Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1982-10-08
1985-08-20
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548453, A61K 3140, C07D48706
Patent
active
045365121
ABSTRACT:
New 5-(2,3-dihydro-1H-pyrrolizin-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]thiazol-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]imidazol-5-oyl)-, and 5-(2,3-dihydro-1H-pyrrolo[2,1-b]oxazol-5-oyl)-derivatives of substituted 2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids have been prepared. They are found to be effective inhibitors of platelet aggregation and are analgesic/anti-inflammatory agents with low ulcerogenic side effects.
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patent: 4087539 (1978-05-01), Muchowski
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Carson and Wong, J. Med. Chem., 16, (2), 172, (1973).
Barker Peter L.
Biftu Tesfaye
Witzel Bruce E.
Cheng Theresa Y.
Hollrah Glennon H.
Merck & Co. , Inc.
Monaco Mario A.
Springer D. B.
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