5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivat

Details 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivat 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivat

1983-09-14

1984-12-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 136, 536 137, 536 138, 536 139, A61K 3171, C07H 1522

Patent

active

044864191

ABSTRACT:
5,2',3',4',4",6"-Hexadeoxykanamycin and 1-N-[(S)-4-amino-2-hydroxybutyryl]-5,2',3',4',4",6"-hexadeoxykanamycin are now provided, which are each a new compound useful as antibacterial agent. The hexadeoxykanamycin is semi-synthetically produced from 3',4'-dideoxykanamycin through consecutive steps which are ingeniously combined with each other to remove the 5-, 2'-, 4"- and 6"-hydroxyl groups. The 1-N-acylated hexadeoxykanamycin is produced by acylating the 1-amino group of hexadeoxykanamycin with (S)-4-amino-2-hydroxybutyric acid.

REFERENCES:
patent: 4298727 (1981-11-01), Umezawa et al.
patent: 4332794 (1982-06-01), Umezawa et al.

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