5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their

Details 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their

1993-07-13

1994-11-22

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514311, 540495, 540557, 540560, A61K 3155, C07D47114

Patent

active

053669720

ABSTRACT:
Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.

REFERENCES:
patent: 4659707 (1987-04-01), Giano et al.
patent: 4873236 (1989-10-01), Engel et al.
Nature, vol. 343, 470-473, Rudi Pauwels, et al.
Chemical Abstracts, vol. 90, No. 17, Apr. 23, 1979, Thomae, Dr. Karl, GmbH, "11-Substituted 5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepine-6-ones.", page 522, col. 1, abstract No. 90:137875s.
Chemical Abstracts, vol. 90, No. 19, May 7, 1979, Brewster, Keith et al., "The Synthesis of some pyrido[1,4]benzoxazepines and a dipyrido[1,4]oxazepine.", page 611, col. 2, abstract No. 90:152145x.
Chemical Abstracts, vol. 71, No. 23, Dec. 8, 1969, Schmidt, Guenther et al., "Analgesic 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones.", p. 394, col. 1, abstract No. 112994z.
Hargrave, Karl D. et al., "Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 1. Tricyclic Pyridobenzo- and Dipyridodiazepines", J. Med. Chem. 1991, 34, 2231-2241.
Merluzzi, Vincent J. et al., "Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor", Science, 1990, 250, 1411-1413.
Koup, Richard A. et al., "Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by the Dipyridodiazepinone BI-RG-587", The Journal of Infectious Diseases, 1991, 163, 966-970.
Wu, Joe C. et al., "A Novel Dipyridodiazepinone Inhibitor of HIV-1 Reverse Transcriptase Acts through a Nonsubstrate Binding Site", Biochemistry, 1991, 30, 2022-2026.

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