5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compou

Details 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compou 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compou

1993-07-12

1995-10-03

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514260, 514259, 514274, 544258, 544287, 536103, A61K 31715, A61K 31505, C08B 3716, C07D47500

Patent

active

054552362

ABSTRACT:
The invention relates to novel cyclodextrin inclusion compounds of 5,10-methylenetetrahydrofolic acid. The surprisingly good stability of these compounds makes possible their pharmaceutical use for the first time. The invention additionally relates to a process for the preparation of the said substances and their use for the preparation of medicaments.

REFERENCES:
patent: 4350659 (1982-09-01), Riceberg
patent: 4447608 (1984-05-01), Jones et al.
patent: 4564616 (1986-01-01), Jones et al.
patent: 4857530 (1989-08-01), Berman et al.
patent: 4959472 (1990-09-01), Wood et al.
patent: 5194611 (1993-03-01), Marazza et al.
Armstrong et al., "Separation of Drug Stereoisomers by the Formation of .beta.-Cyclodextrin Inclusion Complexes", Science, 232:1132-1135 (May 30, 1986).

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