5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-3,4-dih ydroc

Details 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-3,4-dih ydroc 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-3,4-dih ydroc

1974-12-26

1976-08-17

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287R, 260288CE, 260289K, 484258, C07D21526, C07D21522

Patent

active

039753913

ABSTRACT:
5-[1-HYDROXY-2-SUBSTITUTED-AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDROCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) ##SPC1##
wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.1 and R.sup.2 may, when taken together with the nitrogen atom to which they are attached, form a 5 or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the above compounds.

REFERENCES:
patent: 3444173 (1969-05-01), Goldman
Morrison et al. Organic Chemistry, (1969) pp. 666,567,866.
Chodnekar et al. J. Med. Chem. vol. 15 (1972) pp. 49-57.

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