5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyr

Details 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyr 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyr

1974-12-26

1977-05-10

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472A, 260268BQ, 260289K, 42424857, 424250, 42424858, 424258, C07D21526, C07D21522

Patent

active

040227847

ABSTRACT:
5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril derivatives and 5-[1-hydroxy-2-(substituted-amino)]-alkyl-8-substituted-3,4-dihydrocarbost yril derivatives represented by the formulas (Ia) and (Ib) ##STR1## WHEREIN R.sup.1, R.sup.4 and R.sup.5 each represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, with at least one of R.sup.4 and R.sup.5 being an alkyl group, and R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.2 and R.sup.3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the same.

REFERENCES:
patent: 3555030 (1971-01-01), Loev et al.
Morrison et al; Organic Chemistry; (1969); p. 666.
Chodnehar et al; J. Med. Chem.; vol. 15; pp. 49-57, 1972.
Morrison et al; Org. Chem.; (1969) p. 866.
Morrison et al; Org. Chem.; (1969) p. 177.
Burst et al; Arch. Int. Pharmacodyn. vol. 209 (1974) pp. 227-236.
Cantarelli et al., Chem. Abs., vol. 67, 2958a (1967).
Chem. Abs., vol. 62:16212e (abstract of Neth. Appl. 6,405,107) 1965.
Chem. Abs. vol., 81:3968e (1974).

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