5-(1-fluoro-vinyl)-1H-pyrimidine-2,4-dione derivatives useful as

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544313, 544314, C07D40504, C07D23902, A61K 31505

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active

055126782

ABSTRACT:
The present invention provides novel 5-(1-fluorovinyl)-1H-pyrimidine-2,4-dione derivatives which are useful as antineoplastic agents by themselves or in conjunctive therapy with the antineoplastic agent 5-fluorouracil.

REFERENCES:
patent: 4425573 (1983-11-01), Ochi et al.
patent: 4864021 (1989-09-01), Fujii
Tetrahedron Letters, vol. 35, No. 29, 18 Jul. 1994, Oxford GB pp. 5177-5180, Matthews D. P. et al. "The Synthesis of (1-Fuorovinyl) Tributyltin: A Synthetic Equivalent for the 1-Fluoroethene Anion", see p. 5177; Table 1.
Bobek, et al., J. Med. Chem. 30(8):1498-97 (1987).
Coe, et al., J. Med. Chem. 25(11):1329-34 (1982).
Walker, et al., Nucleic Acids Symp. Ser., 11 (Symp. Nucleic Acids Chem., 10th, 1982) 215-218 (1982).
Baerwolf, et al., Nucleic Acids Symp. Ser. 9:45-47 (1981).
Kumar, et al., Eur. J. Med. Chem. 26(5):557-562 (1991).
Farrina, et al., Synlett (3):157-159 (1991).
Coe, et al., CA 97 (19): 163396A (1982).
Walker, et al, CA 98 (11): 83248j (1982).
Balzarini, et al., CA 98 (7): 46574s (1982).
Walker, et al., CA 97 (9): 72715n (1982).
Balzarini, et al., CA 98 (25): 209571e (1982).
Barr, et al., CA 95 (11): 98197d (1981).
Spector, et al., CA 116 (21): 207803y (1992).
Balzarini, et al., CA 108 (17): 142949 (1987).
Balzarini, et al., CA100 (25): 202993V (1984).
Jones, et al., CA96 (25): 218192y (1981).
De Clercq et al., CA 94 (23): 185443d (1981).
Barr, et al., CA 86 (11): 72565m (1976).
Baerwolff, et al., CA 85 (7): 46986j (1975).
De Clercq et al., CA 91(17): 133836c (1979).
Barwolff, D., et al., CA 87, (48) 335428 (1979).
De Clercq, et al., Proc. Natl. Acad. Sci., vol. 76, 6:2947-2951 (1979).
Bleackley, et al., Tetrahedron, 32:2795-2797 (1976).
Baerwolff, et al., CA 109:6907s, p. 660 (1988).
Matthews, D. P. et al., Tetrahedron Letters, vol. 35, No. 7 pp. 1027-1030. (1994).
Balzarine, J. et al, Biochem. Pharmacol., 31(22), 3673-3682 (1982).
Balzarine et al., Proc. Int. Round Tabel Nucleosides, Nucloetides Their Biool. Appl., 4th, Meeting date 1981, 275-291 (1982).
DeClercq etl al., Mol Pharmacol., 19(2), 321-330 (1981).
Baerwolff, D. et al., Nucleic Acids Res. Spec. Publ., 1(Symp. Chem. Nucleic Acids Components, 3rd, 1975), 529-531, (1975).
John A. Wilkinso, Chemical Reviews, 92, 505 (1992).

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