4H-quinolizin-4-ones for treatment of diseases associated with i

Details 4H-quinolizin-4-ones for treatment of diseases associated with i 4H-quinolizin-4-ones for treatment of diseases associated with i

1988-11-10

1990-06-19

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142332, 514256, 514306, 514275, 544127, 544238, 544328, 544333, 544405, 546138, A61K 3150, A61K 31505, A61K 31495, A61K 31435, C07D40114, C07D48706

Patent

active

049354256

ABSTRACT:
This invention provides novel 4H-quinolizin-4-one compounds which exhibit a selective inhibitory activity against IgE-antibody formation, and have utility for treatment of diseases associated with IgE formation in mammals, such as allergic bronchial asthma, allergic rhinitis, atopic dermatitis, hypersensitiveness, and the like.

REFERENCES:
patent: 4650804 (1987-03-01), Kitaura et al.
patent: 4698349 (1987-10-01), Kitaura et al.
Kobayashi et al., Yakugaku ZASSHI, 89(2), 203-208 (1969).
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Kobayashi et al., Chem. Pharm. Bull. 21(5), 921-925 (1973).
Al-Jallo et al., Journal of Heterocyclic Chem. 10(2), 139-142 (1973).
Acheson et al., J.C.S., pp. 1143-1146, 1969.
Kappe et al., Monatish. Chem. 114, 485-493 (1983).
Kobayashi et al., Yakugaku ZASSHI, 97(9) 1039-1045 (1977).
Remers et al., CA76-85664m (1972), "Preparations and Reactions of 6-oxo-5,6,7,8-tetrahydroquinoline".
Kitaura et al., CA104-148759s (1986), "Quinolizinone Compound and Pharmaceutical Composition".
Yagimuma et al., CA106-67676a (1987), "Synthesis or Isolation of Estatin A and Estatin B and . . . ".
Haraguchi et al., J. Med. Chem. 1982, 25, 1495-1499, "A Specific Inhibitor of IgE-Antibody Formation".
Acheson et al., J. Chem. Soc. (c) 1969, 1143-1146, "Addition Reactions of Heterocyclic Compounds . . . ".
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