4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines

Details 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines

1989-07-03

1990-01-30

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540494, 540555, C07D48714, A01K 3155

Patent

active

048973920

ABSTRACT:
There are disclosed compounds having the formula ##STR1## where X is H, halogen, --OH,--OCH.sub.3,--NO.sub.2 or --CF.sub.3 ; Y is H, Cl or Br; Z is H, halogen, --OH or --OCH.sub.3 ; and R is H, loweralkyl, --CH.sub.2 OH or diloweralkylaminomethyl, which compounds are useful as analgesic agents.

REFERENCES:
patent: 3642778 (1972-02-01), Helsley
patent: 3642779 (1972-02-01), Duncan
patent: 4013763 (1977-03-01), Kuwade
patent: 4297280 (1981-10-01), Hirai
Duncan, J. Het Chem 10, 65(1973).
Meguro, Chem Pharm Bull 21, 2382 (1973).
Hester, J. Med Chem 11,1078, (1971).
Hester J. Med Chem 22, 1390 (1979).
Hester J. Med Chem 23, 392 (1980).
Voigtlauder, Drug Development Research, 6 1(1985).

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