4a-Substituted avermectin compounds

Details 4a-Substituted avermectin compounds 4a-Substituted avermectin compounds

1982-08-04

1984-07-03

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424263, 424274, 424279, 549264, 548407, 546 15, 536 71, A61K 31365, C07D49322

Patent

active

044579209

ABSTRACT:
There are disclosed novel avermectin compounds wherein the 4-methyl group is substituted with hydroxy or various groups connected through the hydroxy oxygen atom. The hydroxy compounds are prepared by oxidation of the 4-methyl group and the hydroxy substituents prepared by a substitution process selective for primary alcohols. The compounds have utility as antiparasitic agents and compositions for that use are also disclosed.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4156720 (1979-05-01), Fisher et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4201861 (1980-05-01), Mrozik et al.
patent: 4206205 (1980-06-01), Mrozik et al.

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