4a-Aryl-octahydro-1H-2-pyrindines

Details 4a-Aryl-octahydro-1H-2-pyrindines 4a-Aryl-octahydro-1H-2-pyrindines

1981-02-02

1982-06-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603453, 542400, 542439, 542455, 542469, 546183, 549232, C07D22104, C07D40506

Patent

active

043373410

ABSTRACT:
4a-phenyl and substituted phenyl 2,3,4,4a,5,6,7,7a-octahydro-1H-2-pyrindines having a 2-substituent are disclosed. Such compounds are useful as analgesic agents having mixed agonist and antagonist properties. The compounds can be prepared by reacting an amine with a 4-aryl-2,6-dioxocyclopenta[c]pyran, followed by reduction, or alternatively by alkylating a 4a-aryl-octahydro-1H-2-pyrindine at the 2-position.

REFERENCES:
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patent: 3992387 (1976-11-01), Sturm et al.
patent: 4001247 (1977-01-01), Zimmerman et al.
patent: 4001248 (1977-01-01), Zimmerman et al.
Boekelheide, V., et al., J. Am. Chem. Soc., 72, 712-715, (1950).

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